Drosophila melanogaster as a model to study innate immune memory

Marta Arch; Maria Vidal; Romina Koiffman; Solomon Tibebu Melkie; Pere-Joan Cardona

doi:10.3389/fmicb.2022.991678

Drosophila melanogaster as a model to study innate immune memory

Front Microbiol. 2022 Oct 20:13:991678. doi: 10.3389/fmicb.2022.991678. eCollection 2022.

Authors

Marta Arch^{1

2}, Maria Vidal^{1

2

3

4}, Romina Koiffman^{1

5}, Solomon Tibebu Melkie^{1

5}, Pere-Joan Cardona^{1

2

3

4

6}

Affiliations

¹ Tuberculosis Research Unit, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
² Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
³ Comparative Medicine and Bioimage Centre of Catalonia (CMCiB), Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain.
⁴ Microbiology Department, Laboratori Clínic Metropolitana Nord, Germans Trias i Pujol University Hospital, Badalona, Spain.
⁵ UCBL, UnivLyon, Université Claude Bernard Lyon 1 (UCBL1), Villeurbanne, France.
⁶ Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Abstract

Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, Drosophila melanogaster. This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.

Keywords: Drosophila melanogaster; infection; innate immune memory; resistance; tolerance; trained immunity.

Publication types

Review