2-[3-(4-Chloro-phen-yl)-5-(4-fluoro-phen-yl)-4,5-di-hydro-1 H-pyrazol-1-yl]-5-[(4-fluoro-phen-yl)diazen-yl]-4-methyl-thia-zole

Saud A Alanazi; Bakr F Abdel-Wahab; Amany S Hegazy; Benson M Kariuki; Gamal A El-Hiti

doi:10.1107/S2414314620007002

2-[3-(4-Chloro-phen-yl)-5-(4-fluoro-phen-yl)-4,5-di-hydro-1 H-pyrazol-1-yl]-5-[(4-fluoro-phen-yl)diazen-yl]-4-methyl-thia-zole

IUCrdata. 2020 May 29;5(Pt 5):x200700. doi: 10.1107/S2414314620007002. eCollection 2020 May.

Authors

Saud A Alanazi¹, Bakr F Abdel-Wahab², Amany S Hegazy³, Benson M Kariuki³, Gamal A El-Hiti¹

Affiliations

¹ Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia.
² Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
³ School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, Wales.

Abstract

The mol-ecule of the title compound, C₂₅H₁₈ClF₂N₅S, comprises almost co-planar fluoro-phenyl, methyl-thia-zolyl, pyrazolyl and chloro-phenyl rings with the second fluoro-phenyl ring almost perpendicular to this plane. One fluoro-phenyl group is disordered over two components of occupancy ratio 0.767 (10):0.233 (10) related by a 24.2 (8)° twist. In the crystal, two mol-ecules related by inversion symmetry are linked by a pair of C-H⋯F contacts in an R(8)₂ ² geometry.

Keywords: crystal structure; heterocycles; pyrazole; thiazole.

Grants and funding

The authors are grateful to the Deanship of Scientific Research, King Saud University for funding through the Vice Deanship of Scientific Research Chairs.