Sevoflurane and lipopolysaccharide-induced inflammation differentially affect γ-aminobutyric acid type A receptor-mediated tonic inhibition in the hippocampus of male mice

Shahin Khodaei; Dian-Shi Wang; Yulim Lee; Woosuk Chung; Beverley A Orser

doi:10.1016/j.bja.2022.09.013

Sevoflurane and lipopolysaccharide-induced inflammation differentially affect γ-aminobutyric acid type A receptor-mediated tonic inhibition in the hippocampus of male mice

Br J Anaesth. 2023 Jan;130(1):e7-e10. doi: 10.1016/j.bja.2022.09.013. Epub 2022 Nov 3.

Authors

Shahin Khodaei¹, Dian-Shi Wang¹, Yulim Lee², Woosuk Chung³, Beverley A Orser⁴

Affiliations

¹ Department of Physiology, University of Toronto, Toronto, ON, Canada.
² Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
³ Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea; Department of Anesthesia and Pain Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
⁴ Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address: beverley.orser@utoronto.ca.

PMID: 36336522
DOI: 10.1016/j.bja.2022.09.013

No abstract available

Keywords: GABA(A) receptors; hippocampus; inflammation; lipopolysaccharide; perioperative neurocognitive disorders; sevoflurane; synaptic inhibition; tonic inhibition.

Publication types

Letter

MeSH terms

Animals
Hippocampus / metabolism
Lipopolysaccharides* / pharmacology
Male
Mice
Receptors, GABA*
Receptors, GABA-A / metabolism
Sevoflurane / pharmacology
gamma-Aminobutyric Acid / pharmacology

Substances

Receptors, GABA
Sevoflurane
Lipopolysaccharides
gamma-Aminobutyric Acid
Receptors, GABA-A