Human dentin materials for minimally invasive bone regeneration: Animal studies and clinical cases

Masaru Murata; Takashi Nezu; Hiroaki Takebe; Yukito Hirose; Naoto Okubo; Takashi Saito; Toshiyuki Akazawa

doi:10.1016/j.job.2022.10.003

Human dentin materials for minimally invasive bone regeneration: Animal studies and clinical cases

J Oral Biosci. 2023 Mar;65(1):13-18. doi: 10.1016/j.job.2022.10.003. Epub 2022 Nov 3.

Authors

Masaru Murata¹, Takashi Nezu², Hiroaki Takebe³, Yukito Hirose⁴, Naoto Okubo⁵, Takashi Saito⁶, Toshiyuki Akazawa⁷

Affiliations

¹ Division of Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan. Electronic address: murata@hoku-iryo-u.ac.jp.
² Division of Biomaterials and Bioengineering, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan.
³ Division of Histology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan.
⁴ Division of Fixed Prosthodontics and Oral Implantology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan.
⁵ Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.
⁶ Division of Clinical Cariology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Hokkaido 061-0293, Japan.
⁷ Industrial Technology and Environment Research Development, Hokkaido Research Organization, Kita 19-jo Nishi 11-chome, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

PMID: 36336319
DOI: 10.1016/j.job.2022.10.003

Abstract

Objectives: Bone, platelet concentrate, and tooth-derived dentin/cementum have been used as autologous materials in regenerative medicine Dentin materials were first recycled in 2002 for bone regeneration in humans, although bone autografts were noted in the 19th century, and auto-platelet concentrates were developed in 1998. Dentin/cementum-based material therapy has been applied as an innovative technique for minimally invasive bone surgery, while bone autografts are associated with donor site morbidity.

Methods: In October 2021, PubMed, Google Scholar, Scopus, and the Cochrane Library databases from 1980 to 2020 were screened.

Results: The demineralized dentin/cementum matrix (DDM) had better performance in bone induction and bone regeneration than mineralized dentin.

Conclusions: Unlike cell culture therapy, DDM is a matrix-based therapy that includes growth factors. A matrix-based system is a realistic and acceptable treatment, even in developing countries. The aim of this review was to summarize the evidence related to both animal studies and human clinical cases using human dentin materials with a patch of cementum, especially DDM.

Keywords: Bone regeneration; Demineralized dentin matrix (DDM); Dentin; Graft; Human.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Laboratory
Bone Regeneration*
Dental Cementum
Dentin* / metabolism
Dentin* / transplantation
Humans