Four new sesquiterpenes from Curcuma wenyujin

Lijia Chen; Jingwen Liu; Hong Wang; Yahui Li; Yiming Li; Fujiang Guo

doi:10.1016/j.fitote.2022.105344

Four new sesquiterpenes from Curcuma wenyujin

Fitoterapia. 2022 Nov:163:105344. doi: 10.1016/j.fitote.2022.105344. Epub 2022 Nov 4.

Authors

Lijia Chen¹, Jingwen Liu¹, Hong Wang¹, Yahui Li¹, Yiming Li², Fujiang Guo³

Affiliations

¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
² School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: ymlius@163.com.
³ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: gfj@shutcm.edu.cn.

PMID: 36336136
DOI: 10.1016/j.fitote.2022.105344

Abstract

Four new sesquiterpenes including two guaianes (1 and 2), one germacrene (3), and one nor-sesquiterpene (4), which were named as wenyujinols M-P, along with nine known sesquiterpenes (5-13) and three monoterpenes (14-16), were isolated from the rhizomes of Curcuma wenyujin. The chemical structures of 1-4 were elucidated by NMR spectroscopic, mass spectrometric data, and electronic circular dichroism (ECD) spectra analysis. The isolated compounds were evaluated for antioxidant activity via activating the transcription of Nrf2 in 293 T cells. As a result, compounds 6, 13 and 14 exhibited the Nrf2 agonist activity dose-dependently.

Keywords: Antioxidant activity; Curcuma wenyujin; Sesquiterpenes; Zingiberaceae.

MeSH terms

Curcuma* / chemistry
Molecular Structure
NF-E2-Related Factor 2
Rhizome / chemistry
Sesquiterpenes* / chemistry

Substances

NF-E2-Related Factor 2
Sesquiterpenes