Health threat of PM2.5-bound trace elements exposure on asthma hospital admission: A time-stratified case-crossover study

Yiyi Wang; Yangyang Wu; Feixue Zheng; Ting Zhang; Meng Wang; Lei Huang; Xiaolong Fan; Jinsheng Chen; Naian Xiao

doi:10.1016/j.envint.2022.107604

Health threat of PM_2.5-bound trace elements exposure on asthma hospital admission: A time-stratified case-crossover study

Environ Int. 2022 Dec:170:107604. doi: 10.1016/j.envint.2022.107604. Epub 2022 Oct 28.

Authors

Yiyi Wang¹, Yangyang Wu¹, Feixue Zheng², Ting Zhang¹, Meng Wang³, Lei Huang⁴, Xiaolong Fan⁵, Jinsheng Chen⁶, Naian Xiao⁷

Affiliations

¹ State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
² Aerosol and Haze Laboratory, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
³ Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
⁴ State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China. Electronic address: xlfan@iue.ac.cn.
⁵ Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. Electronic address: huanglei@nju.edu.cn.
⁶ Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
⁷ Department of Neurology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.

PMID: 36334459
DOI: 10.1016/j.envint.2022.107604

Abstract

Environmental pollution of trace elements has become of main concern due to the adverse effects. To estimate the impact of PM_2.5-bound trace elements on human health, a time-stratified case-crossover study has been designed to examine the short-term associations between 28 elements and asthma hospitalizations from January 2019 to November 2021 in Xiamen, China. This research summarized the major components that pose health risks in different seasons and took risk assessment for different groups. We found that an inter-quartile range (IQR) increase of Ca, Fe, Mn, Pd, Si, and Ti was positively associated with the incidence of asthma in the lag of 0-4 days. In winter, the elements that predisposed the population to asthma attack were the most, such as Al, Ba, Ca, Cr, Cu, Fe, K, Mn, Pd, Si, and Ti, and these elements are at higher risk for longer periods of time. The discrepancy in risk levels and major elements of asthma diagnosis among various age groups were also found in this work. Our results provided insights into the development of specific policies to reduce the risk of asthma attacks due to exposure to PM_2.5-bound trace elements.

Keywords: Asthma hospitalization; PM(2.5); Time-stratified; Trace element.

MeSH terms

China / epidemiology
Cross-Over Studies
Hospitals
Humans
Trace Elements* / toxicity

Substances

Trace Elements