Environmental Risks for Inflammatory Myopathies

Weng Ian Che; Ingrid E Lundberg; Marie Holmqvist

doi:10.1016/j.rdc.2022.06.007

Environmental Risks for Inflammatory Myopathies

Rheum Dis Clin North Am. 2022 Nov;48(4):861-874. doi: 10.1016/j.rdc.2022.06.007.

Authors

Weng Ian Che¹, Ingrid E Lundberg², Marie Holmqvist³

Affiliations

¹ Department of Medicine, Solna, Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna, Stockholm 171 76, Sweden; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
² Rheumatology, Karolinska University Hospital, Anna Steckséns gata 30A, Stockholm 171 76, Sweden; Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; ME Gastro, Derm and Rheuma, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden. Electronic address: Ingrid.lundberg@ki.se.
³ Department of Medicine, Solna, Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna, Stockholm 171 76, Sweden; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Rheumatology, Karolinska University Hospital, Anna Steckséns gata 30A, Stockholm 171 76, Sweden; Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

PMID: 36333000
DOI: 10.1016/j.rdc.2022.06.007

Abstract

This is an up-to-date review on external environmental factors for adult-onset idiopathic inflammatory myopathies (IIMs). Environmental factors with suggestive evidence including ultraviolet radiation, smoking, infectious agents (viruses in particular), pollutants, medications (ie, statin) and vitamin D deficiency are discussed. We also discuss the potential implications of environmental factors in IIM development, identify current challenges, and provide insight into future investigations.

Keywords: Antisynthetase syndrome; Environmental factors; Idiopathic inflammatory myopathies; Infectious agents; Myositis; Pollutants; Smoking; Ultraviolet radiation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Autoantibodies
Humans
Myositis* / epidemiology
Myositis* / etiology
Ultraviolet Rays*

Substances

Autoantibodies