Bosniak classification of cystic renal masses, version 2019: Is it helpful to incorporate the diffusion weighted imaging characteristic of lesions into the guideline?

Anqin Li; Shichao Li; Yao Hu; Yaqi Shen; Xuemei Hu; Daoyu Hu; Ihab R Kamel; Zhen Li

doi:10.3389/fonc.2022.1004690

Bosniak classification of cystic renal masses, version 2019: Is it helpful to incorporate the diffusion weighted imaging characteristic of lesions into the guideline?

Front Oncol. 2022 Oct 18:12:1004690. doi: 10.3389/fonc.2022.1004690. eCollection 2022.

Authors

Anqin Li¹, Shichao Li¹, Yao Hu¹, Yaqi Shen¹, Xuemei Hu¹, Daoyu Hu¹, Ihab R Kamel², Zhen Li¹

Affiliations

¹ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, United States.

Abstract

Objective: To improve understanding of diffusion weighted imaging (DWI) characteristic of MRI and clinical variables, further optimize the Bosniak classification for diagnosis of cystic renal masses (CRMs).

Methods: This study retrospectively analyzed 130 CRMs in 125 patients with CT or MRI, including 87 patients with DWI (b = 600, 1000 s/mm2). Clinical variables and histopathological results were recorded. Two radiologists in consensus analyzed images of each lesion for the size, thickness of wall, number of septum, enhancement of wall/septum, wall nodule, signal intensity on DWI, calcification, and cyst content. Clinical variables, CT and MRI image characteristics were compared with pathology or follow-up results to evaluate the diagnostic performance for CRMs.

Results: Of the 130 lesions in 125 patients, histological analysis reported that 36 were malignant, 38 were benign, and no change was found in 56 followed-up lesions (mean follow-up of 24 months). The incidences of cystic wall thickened, more septa, measurable enhancement of wall/septum, nodule(s) on CT/MRI, and high signal intensity on DWI were significantly higher in malignant than in benign CRMs (CT: p = 0.005, p < 0.001, p < 0.001, p < 0.001, p < 0.001; MRI: p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001, p < 0.001). Combination of MRI including DWI features with CT findings showed the highest area under ROC curve (0.973) in distinguishing benign and malignant CRMs.

Conclusions: Incorporating DWI characteristic of CRMs into Bosniak classification helps to improve diagnostic efficiency.

Keywords: Bosniak classification; cystic renal mass; diagnostic performance; diffusion weighted imaging; magnetic resonance imaging.