Effectiveness estimates for enhanced trivalent influenza vaccines in an aged care summer outbreak

Mohana Kunasekaran; Aye Moa; Elmira Hooshmand; Mallory Trent; Christopher J Poulos; Abrar A Chughtai; David J Heslop; C Raina MacIntyre

doi:10.1016/j.vaccine.2022.06.018

Effectiveness estimates for enhanced trivalent influenza vaccines in an aged care summer outbreak

Vaccine. 2022 Nov 28;40(50):7170-7175. doi: 10.1016/j.vaccine.2022.06.018. Epub 2022 Oct 31.

Authors

Mohana Kunasekaran¹, Aye Moa², Elmira Hooshmand², Mallory Trent², Christopher J Poulos³, Abrar A Chughtai⁴, David J Heslop⁴, C Raina MacIntyre²

Affiliations

¹ The University of New South Wales, Kirby Institute, Biosecurity Program, Sydney, New South Wales, Australia. Electronic address: mohanapk@protonmail.com.
² The University of New South Wales, Kirby Institute, Biosecurity Program, Sydney, New South Wales, Australia.
³ The University of New South Wales, School of Population Health, Sydney, New South Wales, Australia; HammondCare, Sydney, New South Wales, Australia.
⁴ The University of New South Wales, School of Population Health, Sydney, New South Wales, Australia.

PMID: 36328885
DOI: 10.1016/j.vaccine.2022.06.018

Abstract

An influenza outbreak occurred during summer (February 2019) in an aged-care facility in Sydney, Australia. Residents had not received the annual 2019 influenza vaccine while 76.7% had received 2018 influenza vaccines about 9 months prior. Overall, 2018 influenza vaccine effectiveness during this outbreak was high (93.6%). The effectiveness of the high-dose trivalent vaccine (HD-TIV) and adjuvanted trivalent (a-TIV) vaccine were 89.8% (95% confidence interval: 18.8%-98.7%) and 72.5% (95% confidence interval: -106.7%-96.3%) respectively. The differences in effectiveness between HD-TIV, a-TIV and SD-QIV, during the summer outbreak were not significant.

Keywords: Adjuvanted trivalent vaccines; Aged care; High-dose trivalent vaccine; Influenza; Outbreak.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic
Aged
Disease Outbreaks / prevention & control
Humans
Influenza Vaccines*
Influenza, Human* / epidemiology
Influenza, Human* / prevention & control
Seasons

Substances

Influenza Vaccines
Adjuvants, Immunologic