Mechanisms of function and clinical potential of exosomes in esophageal squamous cell carcinoma

Lijun Zhao; Lili Yu; Xiangpeng Wang; Jangtao He; Xiaofei Zhu; Rui Zhang; Angang Yang

doi:10.1016/j.canlet.2022.215993

Mechanisms of function and clinical potential of exosomes in esophageal squamous cell carcinoma

Cancer Lett. 2023 Jan 28:553:215993. doi: 10.1016/j.canlet.2022.215993. Epub 2022 Nov 1.

Authors

Lijun Zhao¹, Lili Yu¹, Xiangpeng Wang¹, Jangtao He¹, Xiaofei Zhu², Rui Zhang³, Angang Yang⁴

Affiliations

¹ Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
² Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. Electronic address: zhuxf@xxmu.edu.cn.
³ The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: ruizhang@fmmu.edu.cn.
⁴ Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: agyang@fmmu.edu.cn.

PMID: 36328162
DOI: 10.1016/j.canlet.2022.215993

Abstract

Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal and widespread malignancies in China. Exosomes, a subset of tiny extracellular vesicles manufactured by all cells and present in all body fluids, contribute to intercellular communication and have become a focus of the search for new therapeutic strategies for cancer. A number of global analyses of exosome-mediated functions and regulatory mechanism in malignant diseases have recently been reported. There is extensive evidence that exosomes can be used as diagnostic and prognostic markers for cancer. However, our understanding of their clinical value and mechanisms of action in ESCC is still limited and has not been systematically reviewed. Here, we review current research specifically focused on the functions and mechanisms of action of ESCC tumor-derived exosomes and non-ESCC-derived exosomes in ESCC progression and describe opportunities and challenges in the clinical translation of exosomes.

Keywords: Biomarker; Drug delivery; Esophageal squamous cell carcinoma; Exosome; Novel therapies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
China
Esophageal Neoplasms* / genetics
Esophageal Neoplasms* / pathology
Esophageal Squamous Cell Carcinoma* / pathology
Exosomes* / pathology
Humans