Challenges in TB research

Thomas J Scriba; Ryan Dinkele; Digby F Warner; Valerie Mizrahi

doi:10.1084/jem.20221334

Challenges in TB research

J Exp Med. 2022 Dec 5;219(12):e20221334. doi: 10.1084/jem.20221334. Epub 2022 Nov 3.

Authors

Thomas J Scriba¹, Ryan Dinkele², Digby F Warner^{2

3}, Valerie Mizrahi^{2

3}

Affiliations

¹ South African Tuberculosis Vaccine Initiative, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
² Molecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
³ Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.

Abstract

Tuberculosis (TB) is an infectious disease bedeviled by complexity. This poses myriad challenges for a research ecosystem organized around specialist host- and/or pathogen-focused thrusts. Here, we highlight the key challenges and their implications for developing new tools to control TB.

MeSH terms

Ecosystem
Humans
Mycobacterium tuberculosis*
Tuberculosis*