Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

Rabah Tamimou; Serge Lumbroso; Kevin Mouzat; Jorge Lopez-Castroman

doi:10.3389/fpsyt.2022.1003034

Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

Front Psychiatry. 2022 Oct 17:13:1003034. doi: 10.3389/fpsyt.2022.1003034. eCollection 2022.

Authors

Rabah Tamimou^{1

2

3}, Serge Lumbroso², Kevin Mouzat², Jorge Lopez-Castroman^{1

3

4}

Affiliations

¹ Department of Psychiatry, Nimes University Hospital, Nimes, France.
² Laboratory of Biochemistry and Molecular Biology, Nimes University Hospital, University of Montpellier, Nimes, France.
³ Institut de Génomique Fonctionnelle, University of Montpellier, CNRS-INSERM, Montpellier, France.
⁴ Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.

Abstract

Background/objectives: Immune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for genetic variations potentially altering inflammatory processes in SIB.

Methods: We included studies that looked for associations between SIB and SNPs in genes related to inflammatory processes. Case reports, literature reviews, and animal studies were excluded. Articles were retrieved from PubMed and PsycINFO databases, Google Scholar and GreySource Index until September 17th, 2022. Quality was assessed using Q-Genie.

Results: We analyzed 32 studies. SIB has been associated with eighteen SNPs located in genes encoding for interleukin-8 (rs4073), C-reactive protein (rs1130864), tumor necrosis factor α (rs1800629, rs361525, and rs1099724), tumor necrosis factor receptor 2 (rs1061622), transforming growth factor β-1 (rs1982073), acid phosphatase 1 (rs7419262, rs300774), interleukin-10 (rs1800896), interferon γ (rs2430561), amino-carboxy muconate semialdehyde decarboxylase (rs2121337), interleukin 7 (rs10448044, rs10448042), macrophage migration inhibitory factor (rs755622), interleukin 1-α (rs1800587), and interleukin 1-β (rs1143634 and rs16944. A genome-wide association study reported one association at the threshold of significance with the rs300774 SNP, located in the 2p25 region containing ACP1 gene.

Discussion: The studies included were methodologically and clinically diverse and of moderate quality. Their findings suggest that some inflammation-related SNPs could increase the likelihood of SIB but the evidence to date is insufficient. Further research using gene-gene (GxG) and gene-environment (GxE) approaches is warranted.

Systematic review registration: [https://www.crd.york.ac.uk], identifier [CRD42022296310].

Keywords: SNP; chemokines; cytokines; polymorphism; self-injurious behavior; suicide.

Publication types

Systematic Review