Microneedle-mediated drug delivery for cutaneous diseases

Jian Chen; Hui Ren; Pan Zhou; Shuai Zheng; Bin Du; Xiaowen Liu; Fei Xiao

doi:10.3389/fbioe.2022.1032041

Microneedle-mediated drug delivery for cutaneous diseases

Front Bioeng Biotechnol. 2022 Oct 17:10:1032041. doi: 10.3389/fbioe.2022.1032041. eCollection 2022.

Authors

Jian Chen¹, Hui Ren¹, Pan Zhou², Shuai Zheng², Bin Du³, Xiaowen Liu¹, Fei Xiao¹

Affiliations

¹ Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China.
² Department of Orthopaedics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
³ Department of Pathology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including hydrophilic and hydrophobic small molecular drugs, and macromolecular drugs (proteins, mRNA, peptides, vaccines) for treatment of miscellaneous diseases. Microneedles feature with special benefits for cutaneous diseases owing to the direct transdermal delivery of therapeutics to the skin. This review mainly introduces microneedles fabricated with different technologies and transdermal delivery of various therapeutics for cutaneous diseases, such as psoriasis, atopic dermatitis, skin and soft tissue infection, superficial tumors, axillary hyperhidrosis, and plantar warts.

Keywords: cutaneous disease; drug delivery; microneedle; microneedle fabrication; transdermal route.

Publication types

Review