Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

Muhammad Faisal Manzoor; Zaira Arif; Asifa Kabir; Iqra Mehmood; Danial Munir; Aqsa Razzaq; Anwar Ali; Gulden Goksen; Viorica Coşier; Nazir Ahmad; Murtaza Ali; Alexandru Rusu

doi:10.3389/fnut.2022.994309

Oxidative stress and metabolic diseases: Relevance and therapeutic strategies

Front Nutr. 2022 Oct 17:9:994309. doi: 10.3389/fnut.2022.994309. eCollection 2022.

Authors

Muhammad Faisal Manzoor^{1

2}, Zaira Arif³, Asifa Kabir³, Iqra Mehmood³, Danial Munir³, Aqsa Razzaq³, Anwar Ali^{4

5}, Gulden Goksen⁶, Viorica Coşier⁷, Nazir Ahmad³, Murtaza Ali^{1

2}, Alexandru Rusu^{7

8}

Affiliations

¹ Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan, China.
² School of Food Science and Engineering, South China University of Technology, Guangzhou, China.
³ Department of Nutritional Sciences, Faculty of Medical Sciences, Government College University, Faisalabad, Pakistan.
⁴ Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
⁵ Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, China.
⁶ Department of Food Technology, Vocational School of Technical Sciences at Mersin Tarsus Organized Industrial Zone, Tarsus University, Mersin, Turkey.
⁷ Genetics and Genetic Engineering Department, Animal Science and Biotechnology Faculty, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.
⁸ Life Science Institute, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.

Abstract

Metabolic syndrome (MS) is a prominent cause of death worldwide, posing a threat to the global economy and public health. A mechanism that causes the oxidation of low-density lipoproteins (LDL) is associated with metabolic abnormalities. Various processes are involved in oxidative stress (OS) of lipoprotein. Although the concept of the syndrome has been fiercely debated, this confluence of risk factors is associated with a higher chance of acquiring type 2 diabetes mellitus (T2DM) and atherosclerosis. Insulin resistance has been found to play a significant role in the progression of these metabolism-associated conditions. It causes lipid profile abnormalities, including greater sensitivity to lipid peroxidation, contributing to the increased prevalence of T2DM and atherosclerosis. This review aims to cover the most recent scientific developments in dietary OS, the consequence of metabolic disorders, and their most significant clinical manifestations (T2DM and atherosclerosis). It will also emphasize the effects of dietary approaches in alleviating OS in MS.

Keywords: LDL; a burden on health; metabolic diseases; oxidative stress; therapeutic approaches.

Publication types

Review