Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns

Rosa Grützmann; Christian Kaufmann; Olga A Wudarczyk; Luisa Balzus; Julia Klawohn; Anja Riesel; Katharina Bey; Michael Wagner; Stephan Heinzel; Norbert Kathmann

doi:10.1016/j.bpsgos.2021.07.001

Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns

Biol Psychiatry Glob Open Sci. 2021 Jul 15;2(1):79-87. doi: 10.1016/j.bpsgos.2021.07.001. eCollection 2022 Jan.

Authors

Affiliations

¹ Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
² Department of Psychology, Universität Hamburg, Hamburg, Germany.
³ Department of Psychiatry and Psychotherapy, Universitätsklinikum Bonn, Bonn, Germany.
⁴ Department of Psychology, Freie Universität Berlin, Berlin, Germany.

Abstract

Background: Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in electroencephalography and functional magnetic resonance imaging studies. As most studies used strictly controlled samples (excluding comorbidity and medication), it remains open whether these findings extend to naturalistic settings. Thus, we assessed error-related brain activity in a large, naturalistic OCD sample. We also explored which activity patterns might qualify as vulnerability endophenotypes or protective factors for the disorder. To this aim, a sample of unaffected first-degree relatives of patients with OCD was also included.

Methods: Participants (84 patients with OCD, 99 healthy control participants, and 37 unaffected first-degree relatives of patients with OCD) completed a flanker task while blood oxygen level-dependent responses were measured with functional magnetic resonance imaging. Aberrant error-related brain activity in patients and relatives was identified.

Results: Patients with OCD showed increased error-related activity in the supplementary motor area and within the default mode network, specifically in the precuneus and postcentral gyrus. Unaffected first-degree relatives showed increased error-related activity in the bilateral inferior frontal gyrus.

Conclusions: Increased supplementary motor area and default mode network activity in patients with OCD replicates previous studies and might indicate excessive error signals and increased self-referential error processing. Increased activity of the inferior frontal gyrus in relatives may reflect increased inhibition. Impaired response inhibition in OCD has been demonstrated in several studies and might contribute to impairments in suppressing compulsive actions. Thus, increased inferior frontal gyrus activity in the unaffected relatives of patients with OCD may have contributed to protection from symptom development.

Keywords: Endophenotype; Error monitoring; Family studies; Obsessive-compulsive disorder; Resilience; fMRI.