An ultrasensitive high-performance baicalin sensor based on C3N4-SWCNTs/reduced graphene oxide/cyclodextrin metal-organic framework nanocomposite

Pengcheng Zhao; Linzi Huang; Hui Wang; Chenxi Wang; Jia Chen; Pingping Yang; Meijun Ni; Chao Chen; Chunyan Li; Yixi Xie; Junjie Fei

doi:10.1016/j.snb.2021.130853

An ultrasensitive high-performance baicalin sensor based on C₃N₄-SWCNTs/reduced graphene oxide/cyclodextrin metal-organic framework nanocomposite

Sens Actuators B Chem. 2022 Jan 1:350:130853. doi: 10.1016/j.snb.2021.130853. Epub 2021 Sep 30.

Authors

Pengcheng Zhao^{1

2}, Linzi Huang¹, Hui Wang³, Chenxi Wang^{3

4}, Jia Chen³, Pingping Yang¹, Meijun Ni¹, Chao Chen⁵, Chunyan Li¹, Yixi Xie³, Junjie Fei^{1

4

2}

Affiliations

¹ Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China.
² Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai 200241, People's Republic of China.
³ Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Xiangtan University, Xiangtan 411105, People's Republic of China.
⁴ Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, People's Republic of China.
⁵ College of Materials and Chemical Engineering, Hunan City University, Yiyang 413000, People's Republic of China.

Abstract

Baicalin (Bn) obtained from natural plants has been found to exhibit significant antiviral activity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Herein, a novel ultrasensitive Bn electrochemical sensor was proposed based on graphitized carbon-nitride - single-walled carbon nanotube nanocomposites (C₃N₄-SWCNTs), reduced graphene oxide (rGO) and electrodeposited cyclodextrin-metal organic framework (CD-MOF). The sensing nanomaterials were characterized by X-ray diffraction spectroscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy. Under optimal conditions, the sensor exhibited sensitive detection of Bn in a wide linear range of 1 × 10^-9-5 × 10^-7 M with an LOD of 4.6 × 10^-10 M and a sensitivity of 220 A/M, and it showed satisfactory stability and accuracy for detecting Bn in real samples (human serum and bear bile scutellaria eye drops). In addition, the electrochemical reaction sites and redox mechanism of Bn were revealed through electrochemical behavior and density functional theory. This work provided an insightful solution for detecting Bn, and extensive potential applications could be further expected.

Keywords: Adsorption sensor; Density functional theory; Electrochemical sensor; Flavonoids; MOFs; Supramolecular recognition.