Objective: To explore the dynamic changes of Distress Thermometer scores and the relationship between psychological distress and quality of life in Chinese early breast cancer patients during chemotherapy. Methods: This prospective study enrolled 110 Chinese postoperative early breast cancer patients between March 2019 and December 2019. The psychological distress and quality of life (QOL) of patients were assessed by using the psychological distress management screening tool and the patient quality of life scale. Logistic regression model was used to analyze the influencing factors of psychological distress degree. The correlation between distress thermometer (DT) score changes and quality of life was analyzed by Pearson correlation analysis. Results: In total, 96 valid cases were analyzed. Before chemotherapy, 47 cases (49.0%) had DT score ≥4 points. After 2 cycles of chemotherapy, 40 cases (41.7%) had DT score ≥4 points. Thirty-four patients (35.4%) had DT score ≥4 points after chemotherapy. The DT score after chemotherapy was lower than that before chemotherapy and after 2 cycles of chemotherapy. Univariate analysis showed that income level and pathological stage were still significant related to the detection of DT score ≥4 points after chemotherapy (P<0.05). The changes of DT scores before and after chemotherapy were negatively correlated with the changes of quality of life ( r=-0.298, P=0.003). Conclusions: The detection rate of psychological distress in patients with early breast cancer during chemotherapy showed a decreasing trend. Income level and tumor stage are significant factors affecting the psychological distress of patients. There is a significant correlation between the psychological distress and the quality of life during chemotherapy. We should pay attention to the evaluation and monitoring state of psychological distress of patients during chemotherapy.
目的：分析中国早期乳腺癌患者化疗期间心理痛苦分值动态变化及心理痛苦情况与生活质量的关系。 方法：收集2019年3—12月于北京市朝阳区桓兴肿瘤医院首次接受术后辅助化疗的110例女性乳腺癌患者的临床病理资料。采用心理痛苦管理筛查工具和癌症患者生活质量表评估患者的心理痛苦状况和生活质量情况。影响因素分析采用logistic回归分析，相关分析采用Person相关分析。 结果： 96例患者的有效问卷结果显示，化疗前心理痛苦得分≥4分者占49.0%(47例)，化疗2个周期后心理痛苦得分≥4分者占41.7%(40例)，完成整个化疗周期后心理痛苦得分≥4分者占35.4%(34例)。化疗后痛苦温度计(DT)得分呈逐渐下降趋势。多因素分析显示，患者的月收入水平、肿瘤分期与化疗结束后心理痛苦发生有关(均P<0.05)，月收入水平越高和肿瘤分期越晚的患者越容易产生心理痛苦。患者化疗前、化疗后的DT差值与生活质量差值呈负相关(r＝－0.298，P＝0.003)。 结论：早期乳腺癌患者化疗期间心理痛苦检出率呈下降趋势，月收入水平和肿瘤分期是影响患者心理痛苦的独立影响因素。患者化疗期间心理痛苦与生活质量有关，心理痛苦程度越低、生活质量越高，应加强对早期乳腺癌患者化疗期间心理痛苦状态的评估监测。.
Keywords: Breast neoplasms; Chemotherapy; Psychological distress; Quality of life.