The purpose of the was to compare the antibiotic resistance of the oropharyngeal normoflora in children with frequent Viral respiratory infections (VRIs). Investigated were 33 children in 2016 and 33 children in 2021 who were treated in the Infectious Diseases Department of the Ternopil Regional (Ukraine) Children's Clinical Hospital. The obtained material from the oropharynx from the examined contingent was studied by a generally accepted microbiological method. Determination of antibiotic susceptibility of the selected strains was performed by the method of standard disks. Among surveyed children in 2016 year were 20 (60.60%) carriers of staphylococci, with 12 children of them actually S. aureus. In 2021 were different types of streptococci were isolated from almost half (15 patient) of the subjects: α-hemolytic - 51.60%, β-hemolytic - 45.50% of patients with VRIs and S. aureus. -48.5 %. Analysis of antibiotic susceptibility of staphylococci and streptococci revealed a significant reduction in the number of susceptible staphylococcal strains to cephalosporin and penicillin, moderate - against aminoglycosides and chloramphenicol. Almost all of the studied microorganisms were insensitive to erythromycin. Over the past 5 years, the number of staphylococcal strains sensitive to ceftriaxone decreased by more than 50% (65.0% in 2016 and 14.3% in 2021), to chloramphenicol by 28.7%, ampicillin by 14.4%. The number of streptococci sensitive to all groups of antibiotics decreased by 3-4% 2021 compared to 2016, only to ampicillin the number of sensitive strains decreased by 16%.