MOG-IgG positive optic neuritis after SARS-CoV-2 infection

Eur J Ophthalmol. 2023 Sep;33(5):NP87-NP90. doi: 10.1177/11206721221136319. Epub 2022 Nov 1.

Abstract

Background: Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG.

Objective: To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger.

Methods: Retrospective single case report.

Results: We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection.

Conclusion: This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.

Keywords: immunology < IMMUNOLOGY; infections disease/aids < NEURO OPHTHALMOLOGY; neuro imaging < NEURO OPHTHALMOLOGY; optic neuritis < NEURO OPHTHALMOLOGY; optic neuropathy < NEURO OPHTHALMOLOGY.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies
  • COVID-19*
  • Humans
  • Immunoglobulin G
  • Myelin-Oligodendrocyte Glycoprotein
  • Optic Neuritis* / diagnosis
  • Optic Neuritis* / drug therapy
  • Optic Neuritis* / etiology
  • Retrospective Studies
  • SARS-CoV-2

Substances

  • Myelin-Oligodendrocyte Glycoprotein
  • Autoantibodies
  • Immunoglobulin G