Impact of skeletal muscle loss during conversion therapy on clinical outcomes in lavage cytology positive patients with gastric cancer

Ping'an Ding; Peigang Yang; Li Yang; Chenyu Sun; Shuya Chen; Min Li; Scott Lowe; Honghai Guo; Yuan Tian; Yang Liu; Qun Zhao

doi:10.3389/fonc.2022.949511

Impact of skeletal muscle loss during conversion therapy on clinical outcomes in lavage cytology positive patients with gastric cancer

Front Oncol. 2022 Sep 23:12:949511. doi: 10.3389/fonc.2022.949511. eCollection 2022.

Authors

Ping'an Ding^{1

2}, Peigang Yang^{1

2}, Li Yang³, Chenyu Sun⁴, Shuya Chen⁵, Min Li³, Scott Lowe⁶, Honghai Guo^{1

2}, Yuan Tian^{1

2}, Yang Liu^{1

2}, Qun Zhao^{1

2}

Affiliations

¹ The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
² Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, China.
³ The Department of Computed Tomography (CT)/Magnetic Resonance Imaging (MRI), The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
⁴ AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States.
⁵ Newham University Hospital, London, United Kingdom.
⁶ College of Osteopathic Medicine, Kansas City University, Kansas City, MO, United States.

Abstract

Background: The relationship between sarcopenia and clinical outcomes during conversion therapy in patients with lavage cytology positive gastric cancer (GC-CY₁) remains unclear. This study aimed to investigate the impact of sarcopenia and skeletal muscle loss on the efficacy of conversion therapy, tumour response and survival in GC-CY₁ patients.

Methods: Retrospective analysis of data from a prospective trial of conversion therapy conducted between April 2018 and August 2019 in patients with GC-CY₁ (NCT03718624). Skeletal muscle index (SMI) was measured at the level of the third lumbar (L3) vertebra and the sarcopenia was defined using published cut-off points in all patients. We defined ΔSMI (%)/50 days above 9.53% for men and ΔSMI (%)/50 days above 8.81% for women as significant muscle loss (SML) and analysed the changes in skeletal muscle during conversion therapy in relation to treatment efficacy, survival and tumour response.

Results: Of the 36 patients, 7 patients (19.44%) developed sarcopenia before conversion therapy, 6 (16.67%) developed new sarcopenia after conversion therapy, and 8 (22.22%) developed SML during treatment. Multivariate analysis showed that sarcopenia before treatment [Odds Ratio (OR) =8.923, 95%CI: 1.341-25.321, p=0.002] and SML during treatment (OR=7.803, 95%CI: 1.106-16.189, p=0.001) had a negative impact on the success rate of conversion therapy. Cox multifactorial analysis found that pre-treatment sarcopenia [overall survival (OS): Hazard Ratio (HR) =6.341, 95%CI: 1.269-18.943, p=0.001; progression-free survival (PFS): HR=8.212, 95%CI: 1.569-36.582, p=0.001], newly developed sarcopenia after conversion therapy (OS: HR=3.189, 95%CI: 1.023-9.811, p=0.012; PFS: HR=3.084, 95%CI: 1.042-14.236, p=0.013) and the presence of SML during treatment (OS: HR=10.234, 95%CI: 2.532-54.231, p=0.002; PFS: HR=9.562, 95%CI: 2.341-38.092, p=0.002) were independent risk factor for OS and PFS in GC-CY₁ patients.

Conclusion: Pre-treatment sarcopenia and the presence of SML during treatment are strongly correlated with the immediate and long-term outcomes of GC-CY₁ patients and can be used as imaging markers to predict the treatment efficacy and prognosis of patients in clinical practice.

Keywords: abdominal lavage cytology positive; conversion therapy; gastric cancer; sarcopenia; significant muscle loss; skeletal muscle loss.