The Superiority of 68 Ga-FAPI-04 over 18F-FDG in a Case of Gallbladder Cancer

Chunmei Guo; Dengsai Peng; Ya Liu; Liming Chen; Zhanwen Huang

doi:10.1007/s13139-022-00763-5

The Superiority of ⁶⁸ Ga-FAPI-04 over ¹⁸F-FDG in a Case of Gallbladder Cancer

Nucl Med Mol Imaging. 2022 Oct;56(5):252-255. doi: 10.1007/s13139-022-00763-5. Epub 2022 Aug 5.

Authors

Chunmei Guo^{1

2}, Dengsai Peng^{1

2}, Ya Liu^{1

2}, Liming Chen^{1

2}, Zhanwen Huang^{1

2}

Affiliations

¹ Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000 Sichuan People's Republic of China.
² Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, No. 25, Taiping St, Luzhou, 646000 Sichuan People's Republic of China.

Abstract

A 56-year-old man presented with vague upper abdominal pain for more than 4 months. His abdominal ultrasound and MRI showed thickening of the neck and base of the gallbladder and nodule formation at the base of the gallbladder. ¹⁸F-FDG PET/CT revealed intense FDG uptake in the base of the gallbladder and multiple lymph nodes. ⁶⁸ Ga-FAPI-04 PET/CT not only showed intense FAPI uptake in the above mentioned FDG-avid lesions but also showed intense FAPI uptake in the neck lesion of the gallbladder and some other additional lymph nodes. Finally, histopathological examination confirmed poorly differentiated tubular adenocarcinoma of the neck and base of the gallbladder. Our case illustrated that ⁶⁸ Ga-FAPI-04 PET/CT may outperform ¹⁸F-FDG PET/CT in the detection of gallbladder cancer primary and metastatic lesions.

Keywords: 18F-FDG; 68 Ga-FAPI-04; Gallbladder cancer; PET/CT.

Publication types

Case Reports