Impeded frontal-occipital communications during Go/Nogo tasks in humans owing to mental workload

Abstract

Human brains rely on oscillatory coupling mechanisms for regulating access to prefrontal cognitive resources, dynamically communicating between the frontal and remote cortex. We worry that communications across cortical regions will be impeded when humans in extreme space environments travel with mental load work, affecting the successful completion of missions. Here, we monitored crews of workers performing a Go/Nogo task in space travel, accompanied by acquisitions of electroencephalography (EEG) signals. These data demonstrated that when the target stimulus suddenly changed to the non-target stimulus, an instantaneous communication mechanism between the frontal and occipital cortex was established by theta-gamma phase-amplitude coupling (PAC). However, this frontal-occipital communication was impeded because of the mental workload of space travel. 86 healthy volunteers who participated in the ground imitation further indicated that mental workload caused decoupled theta-gamma PAC during the Go/Nogo task, impeding frontal-occipital communications and behavioral performance. We also found that the degree of theta-gamma PAC coupling in space was significantly lower than on the ground, indicating that mental workload and other hazards worsen the impeded frontal-occipital communications of humans. These results could guide countermeasures for the inadaptability of humans working in spaceflight.

Keywords: EEG; Frontal-occipital communication; Mental workload; Phase-amplitude coupling.