Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide

Leuk Res. 2022 Dec:123:106969. doi: 10.1016/j.leukres.2022.106969. Epub 2022 Oct 22.

Authors

Neal Shah¹, Joseph Cioccio¹, Kevin Rakszawski¹, Hong Zheng¹, Myles Nickolich¹, Seema Naik¹, Baldeep Wirk¹, Witold Rybka¹, Christopher Ehmann¹, Brook Silar¹, Caitlin Vajdic¹, Joseph Mierski¹, Shouhao Zhou¹, Hiroko Shike¹, Robert Greiner¹, Valerie Brown¹, Raymond Hohl¹, David Claxton¹, Shin Mineishi¹, Kentaro Minagawa², Leonard Tuanquin¹

Affiliations

¹ Penn State Cancer Institute, and Penn State Children's Hospital, 500 University Dr., Hershey, PA 17033, USA.
² Penn State Cancer Institute, and Penn State Children's Hospital, 500 University Dr., Hershey, PA 17033, USA. Electronic address: kminagawa@pennstatehealth.psu.edu.

PMID: 36306723
DOI: 10.1016/j.leukres.2022.106969

No abstract available

Keywords: Chimerism analysis; PTCy; T-cell chimerism analysis; TBI.

Publication types

Letter

MeSH terms

Chimerism
Cyclophosphamide
Graft vs Host Disease* / etiology
Graft vs Host Disease* / prevention & control
Hematopoietic Stem Cell Transplantation*
Humans
T-Lymphocytes
Transplantation Conditioning
Whole-Body Irradiation

Substances

Cyclophosphamide