Posttraumatic Stress Disorder (PTSD) as a Risk Factor for Cardiovascular Disease: Implications for Future Research and Clinical Care

Curr Cardiol Rep. 2022 Dec;24(12):2067-2079. doi: 10.1007/s11886-022-01809-y. Epub 2022 Oct 28.

Abstract

Purpose of review: Posttraumatic stress disorder (PTSD) may be an important risk factor for cardiovascular disease (CVD). We explore the literature linking PTSD to CVD, potential mechanisms, interventions, and clinical implications. We outline gaps in current literature and highlight necessary future research.

Recent findings: PTSD has been independently associated with deleterious effects on cardiovascular health through biological, behavioral, and societal pathways. There are evidence-based psychotherapeutic interventions and pharmacotherapies for PTSD that may mitigate its impact on CVD. However, there are limited studies that rigorously analyze the impact of treating PTSD on cardiovascular outcomes. Trauma-informed CVD risk stratification, education, and treatment offer opportunities to improve patient care. These approaches can include a brief validated screening tool for PTSD identification and treatment. Pragmatic trials are needed to test PTSD interventions among people with CVD and evaluate for improved outcomes.

Keywords: CVD; Cardiac risk factors; Cardiovascular disease; PTSD; Posttraumatic stress disorder; Risk factors.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cardiovascular Diseases* / complications
  • Humans
  • Risk Factors
  • Stress Disorders, Post-Traumatic* / complications
  • Stress Disorders, Post-Traumatic* / therapy