Laboratory prognostic factors for the long-term survival of multiple system atrophy

Jung Hwan Shin; Han-Joon Kim; Chan Young Lee; Hee Jin Chang; Kyung Ah Woo; Beomseok Jeon

doi:10.1038/s41531-022-00413-9

Laboratory prognostic factors for the long-term survival of multiple system atrophy

NPJ Parkinsons Dis. 2022 Oct 27;8(1):141. doi: 10.1038/s41531-022-00413-9.

Authors

Jung Hwan Shin¹, Han-Joon Kim², Chan Young Lee³, Hee Jin Chang¹, Kyung Ah Woo¹, Beomseok Jeon¹

Affiliations

¹ Department of Neurology, Seoul National University Hospital & Seoul National University College of Medicine, Seoul, South Korea.
² Department of Neurology, Seoul National University Hospital & Seoul National University College of Medicine, Seoul, South Korea. movement@snu.ac.kr.
³ Department of Neurology, School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea.

Abstract

To elucidate the biomarkers related to survival in multiple system atrophy(MSA), we analyzed the predictability of retrospectively collected blood markers for survival in 650 probable MSA. High absolute neutrophil count, red-cell distribution width, C-reactive protein, erythrocyte sedimentation rate, and low hemoglobin, protein, albumin, and creatinine were correlated with higher mortality in MSA. Systemic alteration in inflammation and nutritional status in the early stage are associated with higher mortality in MSA.