Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane

Tomaso Caporossi; Lorenzo Governatori; Gloria Gambini; Antonio Baldascino; Umberto De Vico; Matteo Ripa; Alessandra Scampoli; Matteo Mario Carlà; Clara Rizzo; Raphael Kilian; Stanislao Rizzo

doi:10.1007/s10384-022-00953-w

Treatment of recurrent high myopic macular hole associated with retinal detachment using a human amniotic membrane

Jpn J Ophthalmol. 2022 Nov;66(6):518-526. doi: 10.1007/s10384-022-00953-w. Epub 2022 Oct 27.

Authors

Tomaso Caporossi^{1

2}, Lorenzo Governatori³, Gloria Gambini^{1

2}, Antonio Baldascino^{1

2}, Umberto De Vico^{1

2}, Matteo Ripa¹, Alessandra Scampoli^{1

2}, Matteo Mario Carlà^{1

2}, Clara Rizzo⁴, Raphael Kilian⁵, Stanislao Rizzo^{1

2

6}

Affiliations

¹ Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
² Catholic University Sacro Cuore, Rome, Italy.
³ Department of Neurofarba, Ophthalmology, University of Florence, Florence, Italy. lorenzo.gov@gmail.com.
⁴ Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.
⁵ Ophthalmology Unit, University of Verona, Verona, Italy.
⁶ Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Pisa, Italy.

PMID: 36301445
DOI: 10.1007/s10384-022-00953-w

Abstract

Purpose: To determine the efficacy of using a human amniotic membrane to close macular hole retinal detachment in highly myopic eyes.

Study design: Prospective, consecutive, nonrandomized interventional study.

Methods: We included 19 high myopic eyes from 19 patients affected by macular hole retinal detachment who had already undergone vitrectomy with internal limiting membrane peeling. The patients underwent vitrectomy with amniotic membrane transplant.

Results: Primary success was achieved after 3 months in 89.5% (17 of 19 eyes) and final macular hole closure was obtained in 94.7% (18 of 19 eyes) of the patients. The final retinal reattachment rate was 100%. The final 12-month mean BCVA improved from 20/2000 (2 logMAR) to 20/250 (1.1 logMAR). OCT-angiography revealed a high correlation between the superficial and deep capillary plexus and the final BCVA.

Conclusion: Human amniotic membrane patches can effectively repair macular hole retinal detachment in high myopic eyes in terms of anatomic results and BCVA recovery.

Keywords: High myopia; Human amniotic membrane; Macular hole; OCT-angiography; Retinal detachment.

Publication types

Clinical Trial

MeSH terms

Amnion
Basement Membrane / surgery
Humans
Myopia, Degenerative* / complications
Myopia, Degenerative* / diagnosis
Prospective Studies
Retinal Detachment* / diagnosis
Retinal Detachment* / etiology
Retinal Detachment* / surgery
Retinal Perforations* / diagnosis
Retinal Perforations* / etiology
Retinal Perforations* / surgery
Retrospective Studies
Tomography, Optical Coherence
Visual Acuity
Vitrectomy / methods