Population Genetic Data of 30 Insertion-Deletion Markers in the Polish Population

Genes (Basel). 2022 Sep 20;13(10):1683. doi: 10.3390/genes13101683.

Abstract

(1) Background: Insertion-deletion (InDel) markers show the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) and are considered alternative markers in forensic genetics. (2) Methods: Allelic frequencies and corresponding forensic efficiency parameters of 30 autosomal polymorphic InDel loci included in the Investigator DIPplex kit (Qiagen) were obtained in a sample of 631 unrelated Polish individuals. Allelic frequency data were compared with those reported for selected populations (3) Results: All the loci conformed with Hardy-Weinberg equilibrium after applying a Bonferroni correction and no pair-wise significant linkage disequilibrium was detected. (4) Conclusions: DIPplex Kit differences were high among populations worldwide. The InDel markers are highly discriminating for human identification purposes in the Polish population.

Keywords: InDels; Investigator DIPplex; Poland; forensic genetics; population.

MeSH terms

  • Gene Frequency / genetics
  • Genetics, Population*
  • Humans
  • INDEL Mutation*
  • Poland
  • Polymorphism, Single Nucleotide / genetics

Grants and funding

This research received no external funding.