Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

A Cousins; O Olivares; E Markert; A Manoharan; X Bubnova; S Bresolin; M Degn; Z Li; D Silvestri; G McGregor; S Tumanov; D Sumpton; J J Kamphorst; A M Michie; P Herzyk; M G Valsecchi; A E Yeoh; K Schmiegelow; G Te Kronnie; E Gottlieb; C Halsey

doi:10.1038/s41375-022-01722-x

Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

Leukemia. 2022 Dec;36(12):2903-2907. doi: 10.1038/s41375-022-01722-x. Epub 2022 Oct 26.

Authors

A Cousins¹, O Olivares¹, E Markert^{1

2}, A Manoharan¹, X Bubnova¹, S Bresolin³, M Degn⁴, Z Li⁵, D Silvestri⁶, G McGregor^{1

2}, S Tumanov², D Sumpton², J J Kamphorst^{1

2}, A M Michie⁷, P Herzyk^{8

9}, M G Valsecchi⁶, A E Yeoh^{5

10}, K Schmiegelow^{4

11}, G Te Kronnie¹², E Gottlieb¹³, C Halsey¹⁴

Affiliations

¹ Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
² Cancer Research UK Beatson Institute, Glasgow, UK.
³ Department of Women's and Children's Health, University of Padova, Padova, Italy.
⁴ Department of Pediatrics and Adolescent Medicine, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark.
⁵ VIVA-NUS Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore.
⁶ Center of Biostatistics for Clinical Epidemiology, Department of Health Science, University of Milano-Bicocca, Milano, Italy.
⁷ Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
⁸ Glasgow Polyomics, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
⁹ Institute of Molecular, Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
¹⁰ VIVA-University Children's Cancer Centre, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore, 119228, Singapore.
¹¹ Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark.
¹² Department of Molecular Medicine, University of Padova, Padova, Italy.
¹³ The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
¹⁴ Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Chris.Halsey@glasgow.ac.uk.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosynthetic Pathways
Central Nervous System
Central Nervous System Neoplasms*
Cholesterol
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Up-Regulation

Substances

Cholesterol

Publication types

MeSH terms

Substances

Grants and funding