Lineage switch from acute myeloid leukemia to B-lymphoblastic lymphoma with an acquired PIK3R1 loss-of-function mutation

Am J Hematol. 2023 Jan;98(1):E1-E3. doi: 10.1002/ajh.26770. Epub 2022 Nov 4.

Authors

Monica Aldulescu¹, Katrin Leuer¹, Lawrence J Jennings¹, Kai Lee Yap¹, Shunyou Gong¹

Affiliation

¹ Departments of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 36288429
DOI: 10.1002/ajh.26770

No abstract available

Publication types

Letter

MeSH terms

Cell Lineage
Class Ia Phosphatidylinositol 3-Kinase / genetics
Humans
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / pathology
Lymphoma, B-Cell*
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / pathology

Substances

PIK3R1 protein, human
Class Ia Phosphatidylinositol 3-Kinase