Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery

Rubiya Khursheed; Monica Gulati; Sheetu Wadhwa; Sukriti Vishwas; Deep Shikha Sharma; Leander Corrie; Aftab Alam; Sulaiman Mohammed Alnasser; Faris F Aba Alkhayl; Zeenat Parveen; Srinivas Nammi; Dinesh Kumar Chellappan; Gaurav Gupta; Flavia Zacconi; Amie Steel; Jon Adams; Niraj Kumar Jha; Kamal Dua; Sachin Kumar Singh

doi:10.1016/j.cbi.2022.110223

Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery

Chem Biol Interact. 2022 Dec 1:368:110223. doi: 10.1016/j.cbi.2022.110223. Epub 2022 Oct 22.

Authors

Rubiya Khursheed¹, Monica Gulati², Sheetu Wadhwa¹, Sukriti Vishwas¹, Deep Shikha Sharma¹, Leander Corrie¹, Aftab Alam³, Sulaiman Mohammed Alnasser⁴, Faris F Aba Alkhayl⁵, Zeenat Parveen⁶, Srinivas Nammi⁷, Dinesh Kumar Chellappan⁸, Gaurav Gupta⁹, Flavia Zacconi¹⁰, Amie Steel¹¹, Jon Adams¹¹, Niraj Kumar Jha¹², Kamal Dua¹³, Sachin Kumar Singh¹⁴

Affiliations

¹ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
² School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
³ Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia.
⁴ Pharmacology and Toxicology Department, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia.
⁵ Department of Pharmaceutical Chemistry and Pharmacognosy, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Saudi Arabia; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
⁶ CT Institute of Pharmaceutical Sciences, CT University, Jalandhar, India.
⁷ School of Science, Western Sydney University, Penrith, NSW, 2751, Australia.
⁸ Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
⁹ School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹⁰ Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, Macul, Santiago, 7820436, Chile.
¹¹ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
¹² Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No.32-34 Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India.
¹³ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW, 2007, Australia.
¹⁴ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia. Electronic address: singhsachin23@gmail.com.

PMID: 36283466
DOI: 10.1016/j.cbi.2022.110223

Abstract

Synbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.

Keywords: Colon targeted drug delivery; Encapsulation; Gut dysbiosis; SNEDDS; Synbiotics.

Publication types

Review

MeSH terms

Dysbiosis
Excipients
Humans
Prebiotics
Probiotics* / pharmacology
Probiotics* / therapeutic use
Synbiotics*

Substances

Prebiotics
Excipients