Did circular DNA shape the evolution of mammalian genomes?

Sylvester Holt; Gerard Arrey; Birgitte Regenberg

doi:10.1016/j.tibs.2022.09.010

Did circular DNA shape the evolution of mammalian genomes?

Trends Biochem Sci. 2023 Apr;48(4):317-320. doi: 10.1016/j.tibs.2022.09.010. Epub 2022 Oct 21.

Authors

Sylvester Holt¹, Gerard Arrey¹, Birgitte Regenberg²

Affiliations

¹ Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark.
² Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark. Electronic address: bregenberg@bio.ku.dk.

PMID: 36280496
DOI: 10.1016/j.tibs.2022.09.010

Abstract

Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.

Keywords: deletion; eccDNA; evolution; mammal; meiosis; synteny; transposition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA, Circular* / genetics
Mammals* / genetics

Substances

DNA, Circular