Prognostication in inflammatory bowel disease

Elizabeth A Spencer; Manasi Agrawal; Tine Jess

doi:10.3389/fmed.2022.1025375

Prognostication in inflammatory bowel disease

Front Med (Lausanne). 2022 Oct 6:9:1025375. doi: 10.3389/fmed.2022.1025375. eCollection 2022.

Authors

Elizabeth A Spencer¹, Manasi Agrawal^{2

3}, Tine Jess^{3

4}

Affiliations

¹ Division of Pediatric Gastroenterology and Nutrition, Icahn School of Medicine, Mount Sinai Hospital, New York, NY, United States.
² Division of Gastroenterology, Icahn School of Medicine, Mount Sinai Hospital, New York, NY, United States.
³ Center for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Aalborg University, Aalborg, Denmark.
⁴ Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Abstract

Personalized care in inflammatory bowel diseases (IBD) hinges on parsing the heterogeneity of IBD patients through prognostication of their disease course and therapeutic response to allow for tailor-made treatment and monitoring strategies to optimize care. Herein we review the currently available predictors of outcomes in IBD and those on the both near and far horizons. We additionally discuss the importance of worldwide collaborative efforts and tools to support clinical use of these prognostication tools.

Keywords: Crohn's disease; inflammatory bowel disease; precision medicine; prognostication; ulcerative colitis.

Publication types

Review

Grants and funding

K23 DK125760/DK/NIDDK NIH HHS/United States