Metallic and metal oxide-derived nanohybrid as a tool for biomedical applications

Mohd Hasan Mujahid; Tarun Kumar Upadhyay; Fahad Khan; Pratibha Pandey; Moon Nyeo Park; Amit Baran Sharangi; Mohd Saeed; Vijay J Upadhye; Bonglee Kim

doi:10.1016/j.biopha.2022.113791

Metallic and metal oxide-derived nanohybrid as a tool for biomedical applications

Biomed Pharmacother. 2022 Nov:155:113791. doi: 10.1016/j.biopha.2022.113791. Epub 2022 Oct 7.

Authors

Mohd Hasan Mujahid¹, Tarun Kumar Upadhyay², Fahad Khan³, Pratibha Pandey³, Moon Nyeo Park⁴, Amit Baran Sharangi⁵, Mohd Saeed⁶, Vijay J Upadhye¹, Bonglee Kim⁷

Affiliations

¹ Department of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara, Gujarat, 391760, India.
² Department of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara, Gujarat, 391760, India. Electronic address: tarun_bioinfo@yahoo.co.in.
³ Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India.
⁴ Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea.
⁵ Department of Plantation, Spices, Medicinal & Aromatic Crops, BCKV-Agricultural University, Mohanpur, 741252 Nadia, West Bengal, India.
⁶ Department of Biology, College of Sciences, University of Hail, PO BOX 2240, Hail, Saudi Arabia.
⁷ Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, South Korea. Electronic address: bongleekim@khu.ac.kr.

PMID: 36271568
DOI: 10.1016/j.biopha.2022.113791

Abstract

Nanotechnology covers a variety of scientific areas including chemistry, material science, physics, biomedicine, biology, and engineering. Metal nanohybrid with extraordinary properties is highly researched in comparison to bulky individual nanoparticles. Especially, metal and metal oxide nanoparticles are a new class of functional nanohybrids having broad, intriguing physio-chemical properties showing applications in nanoscience and biomedical research. Engineered inorganic nanoparticles have paved an essential component in the advancement of nanotechnologies. Synthesis is done through various physical, chemical, and biological methods with their special features and manipulation at the nano level in their physiochemical properties, controlling their shape, size, and surface functionality. Application of metal and metal oxide nanohybrid are discussed, including, gene delivery, theranostics, and catalysis. Due to the versatile application of nanohybrids, it can be used in the detection of tumors, cell tracking, and visualizing the specific region of disease. Development of accurate, multifunctional imaging and ambient data are indispensable for futuristic applications. Nanohybrids (NHs) can load therapeutic drugs in their sector of core and shell and have the ability to release them in a controlled and sequential manner of a delivery system. Novel nanohybrid with their multidimensional, integrated mechanistic property has also shown a great effect on environmental pollution control also. A proteomics and transcriptomics approach for the nanohybrid action of mechanism has been discussed and also includes limitations of MNHs and MONHs. The current manuscript critically reviewed several available recent kinds of literature and has the potential to offer a better understanding of metallic and metallic oxide nanohybrids having a multifunctional role in various biomedical applications.

Keywords: Metal nanohybrids; Metal oxide nanohybrids; Nanobiotechnology, nanoparticles; Nanohybrids; Nanotechnology.

Publication types

Review

MeSH terms

Catalysis
Gene Transfer Techniques
Metal Nanoparticles* / chemistry
Nanotechnology
Oxides*

Substances

Oxides