A 58S bioactive glass for dentin hypersensitivity and erosive tooth wear: An in vitro study

Ítallo Emídio Lira Viana; Roger Borges; Juliana Marchi; Sabrina Feitosa; Márcia Martins Marques; Taís Scaramucci

doi:10.1016/j.jdent.2022.104343

A 58S bioactive glass for dentin hypersensitivity and erosive tooth wear: An in vitro study

J Dent. 2022 Dec:127:104343. doi: 10.1016/j.jdent.2022.104343. Epub 2022 Oct 19.

Authors

Ítallo Emídio Lira Viana¹, Roger Borges², Juliana Marchi², Sabrina Feitosa³, Márcia Martins Marques⁴, Taís Scaramucci⁵

Affiliations

¹ Department of Restorative Dentistry, School of Dentistry, University of Sao Paulo, 2227 Professor Lineu Prestes Avenue, São Paulo, SP 05508-000, Brazil.
² Center for Natural Sciences and Humanities, Federal University of ABC, Santo André, SP, Brazil.
³ Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN, USA.
⁴ Post-Graduation Program, School of Dentistry, Universidade Ibirapuera, São Paulo, SP, Brazil.
⁵ Department of Restorative Dentistry, School of Dentistry, University of Sao Paulo, 2227 Professor Lineu Prestes Avenue, São Paulo, SP 05508-000, Brazil. Electronic address: tais.sca@usp.br.

PMID: 36270541
DOI: 10.1016/j.jdent.2022.104343

Abstract

Objectives: To assess the effect of an experimental 58S bioactive glass on dentin permeability (dP) and erosive tooth wear (dentin surface loss - dSL).

Methods: 58S bioactive glass was synthetized using a sol-gel methodology, following by lyophilization and calcination, then mixed with phosphoric acid to obtain a paste (BGP). Forty-eight dentin disks (1 mm-thick) were used for dP, and 48 dentin slabs (3 mm × 3 mm) for dSL, which were assessed at three time intervals: post-EDTA (5 min in 17% EDTA solution); post-treatment (C: distilled water; BGP: experimental bioactive glass paste; NP: Nupro prophylaxis paste; CXT: Clinpro XT varnish); and post-erosive/abrasive cycling. Data were statistically analyzed (α=0.05).

Results: For dP and dSL, Groups did not differ significantly post-EDTA (p>0.05). Post-treatment, all groups showed lower dP than C (p<0.05), without differing significantly among them. For the dSL analysis, Groups C, BGP and NP did not differ significantly, showing lower values than CXT (p<0.05). Post-cycling, C continued to show the highest dP (p<0.05). Specimens from Group CXT had the lowest dP and did not differ from NP (p=0.86) which did not differ from BGP (p=0.193). For C and BGP, dP value was higher post-cycling than post-treatment (p<0.05). For NP and CXT, these experimental times did not differ (p>0.05). Post-cycling, dSL for C, BGP and NP did not differ significantly; values were higher than those for CXT (p<0.05).

Conclusions: BGP reduced dP after application, with a reduced effect after cycling. Nonetheless, it was not able to protect dentin against erosive tooth wear.

Clinical significance: Minimizing dentin hypersensitivity is a challenge in the field of dentistry. The development of alternative products with potential to obliterate dentinal tubules and provide resistance to chemical/mechanical stimuli is, thus, highly desirable. We have proposed a material able to reduce dentin permeability, which has emerged as a promising alternative for this purpose.

Keywords: Bioactive glass; Dentin hypersensitivity; Dentin permeability; Erosive tooth wear; Optical profilometry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dentin
Dentin Sensitivity* / drug therapy
Edetic Acid / pharmacology
Edetic Acid / therapeutic use
Humans
Microscopy, Electron, Scanning
Tooth Attrition*
Tooth Erosion* / prevention & control
Tooth Wear*

Substances

bioactive glass 58S
Edetic Acid