Three new compounds with their anti-glioma effects from the roots of Arnebia guttata Bunge

Yu-Mei Yan; Lin-Jun Zou; Min-Hui Li; Zhao-Cui Sun; Min Zhang; Xu-Dong Xu; Chun-Hong Zhang

doi:10.1080/14786419.2022.2136658

Three new compounds with their anti-glioma effects from the roots of Arnebia guttata Bunge

Nat Prod Res. 2023 Aug-Sep;37(17):2817-2823. doi: 10.1080/14786419.2022.2136658. Epub 2022 Oct 20.

Authors

Yu-Mei Yan¹, Lin-Jun Zou², Min-Hui Li^{1

3}, Zhao-Cui Sun², Min Zhang¹, Xu-Dong Xu², Chun-Hong Zhang^{1

3}

Affiliations

¹ Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, China.
² Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China.
³ Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, China.

PMID: 36268558
DOI: 10.1080/14786419.2022.2136658

Abstract

Three new compounds, arneatas A-C (1-3), together with three known compounds (4-6) were isolated from the roots of Arnebia guttata Bunge. The structures were established on the basis of extensive spectroscopic data including NMR and HRESIMS. All the new compounds (1-3) were tested for their cytotoxic activity against two glioma cell lines (U118-MG and U373-MG) in vitro after treatment for 48 h. Compound 1 exhibited moderate cytotoxic activity against U118-MG and U373-MG glioma cell lines, with IC₅₀ values of 10.4 and 17.5 µM, respectively.

Keywords: Arnebia guttata Bunge; anti-glioma effects; chemical constituents; cytotoxicity.