Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy

Saikat Dewanjee; Pratik Chakraborty; Hiranmoy Bhattacharya; Sachin Kumar Singh; Kamal Dua; Abhijit Dey; Niraj Kumar Jha

doi:10.1016/j.drudis.2022.103409

Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy

Drug Discov Today. 2023 Jan;28(1):103409. doi: 10.1016/j.drudis.2022.103409. Epub 2022 Oct 17.

Authors

Saikat Dewanjee¹, Pratik Chakraborty², Hiranmoy Bhattacharya², Sachin Kumar Singh³, Kamal Dua⁴, Abhijit Dey⁵, Niraj Kumar Jha⁶

Affiliations

¹ Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: saikat.dewanjee@jadavpuruniversity.in.
² Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
³ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
⁴ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia.
⁵ Department of Life Sciences, Presidency University, Kolkata 700073, West Bengal, India. Electronic address: abhijit.dbs@presiuniv.ac.in.
⁶ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, India; Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India. Electronic address: nirajkumarjha2011@gmail.com.

PMID: 36265733
DOI: 10.1016/j.drudis.2022.103409

Abstract

Flavonoids are an interesting class of biomolecules, which exhibit cancer-inhibitory effects through both chemopreventive and chemotherapeutic activities. However, their therapeutic efficacy is affected by poor pharmacokinetics (PK) and biopharmaceutical attributes. One of the most promising approaches to resolve these issues is to formulate flavonoids in nanosystems. Different flavonoid nanoformulations have shown therapeutic superiority over free flavonoids. Functionalization of nanoparticles (NPs) further improves their therapeutic efficacy by facilitating site-specific delivery and reducing nonspecific toxicities. In this review, we highlight recent developments in the field of flavonoid-based NPs to gain translational insights into the potential applications of flavonoid-based nanocarriers in cancer management.

Keywords: bioavailability; cancer therapeutics; flavonoids; nanocarriers; site-specific delivery.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers
Drug Delivery Systems
Flavonoids / therapeutic use
Humans
Nanoparticles*
Neoplasms* / drug therapy

Substances

Drug Carriers
Flavonoids