Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

Yan Jiang; Jing-Chuan Yuan; Ge Song; Xu-Hui Zhang; Sui-Bing Miao; Xiao-Hua Wu

doi:10.1186/s12884-022-05114-y

Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

BMC Pregnancy Childbirth. 2022 Oct 19;22(1):779. doi: 10.1186/s12884-022-05114-y.

Authors

Yan Jiang¹, Jing-Chuan Yuan², Ge Song², Xu-Hui Zhang², Sui-Bing Miao², Xiao-Hua Wu²

Affiliations

¹ The Center for Reproductive Medicine and Infertility, The Fourth Hospital of Shijiazhuang, Shijiazhuang Obstetrics and Gynecology Hospital affiliated to Hebei Medical University, 206 Zhong-Shan-Dong, Shijiazhuang, Hebei, 050011, People's Republic of China. 13932117427@163.com.
² The Center for Reproductive Medicine and Infertility, The Fourth Hospital of Shijiazhuang, Shijiazhuang Obstetrics and Gynecology Hospital affiliated to Hebei Medical University, 206 Zhong-Shan-Dong, Shijiazhuang, Hebei, 050011, People's Republic of China.

Abstract

Background: The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and offspring follow-up in patients with PCOS as the recipients are unclear. This study was to compare the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor.

Methods: This was a retrospective cohort study of 62 patients undergoing the oocyte reception program were separated into 2 groups: Group I, PCOS oocyte recipients (n = 30); Group II, non-PCOS recipients (n = 32). Medical records were reviewed, and rates of fertilization, cleavage, high-quality embryos and blastocysts were compared between PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancies, and offspring outcomes were calculated using the first single vitrified-warmed blastocyst transfer (SVBT) analysis between the groups.

Results: The average recipient age and body mass index (BMI) of PCOS and non-PCOS patients was (36.3 ± 2.6 vs. 36.2 ± 2.8, and 23.4 ± 3.9 vs. 23.7 ± 4.0), respectively (P > 0.05). The fertilization, cleavage, high-quality embryos and blastocyst rates were not significantly different between the PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancies were not significantly different in SVBT between the PCOS and non-PCOS groups. The incidence of complications, such as pre-eclampsia or gestational diabetes, between PCOS and non-PCOS groups was similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm births were also similar (11.8% vs.16.7%, P > 0.05). Donor oocytes are more likely to be delivered via cesarean Sect. (80.0% vs. 86.7%: P > 0.05). The mean gestational age, birth weight, and height were comparable between the 2 groups during full-term delivery.

Conclusion: There was no difference in the pregnancy outcomes and follow-up of the offspring between the PCOS and non-PCOS groups.

Keywords: Birth offspring; Oocyte donation; PCOS; Pregnancy outcome.

MeSH terms

Female
Follow-Up Studies
Humans
Oocytes
Polycystic Ovary Syndrome* / complications
Polycystic Ovary Syndrome* / epidemiology
Pregnancy
Pregnancy Outcome / epidemiology
Pregnancy, Ectopic*
Retrospective Studies