Cytomegalovirus Oophoritis Mimicking Burkitt's Lymphoma Recurrence: A Case Report and Literature Review

Intern Med. 2023 Jun 15;62(12):1861-1866. doi: 10.2169/internalmedicine.0517-22. Epub 2022 Oct 19.

Abstract

Cytomegalovirus (CMV) oophoritis is an extremely rare and fatal condition. We encountered a 63-year-old woman with CMV oophoritis who had been treated for Burkitt's lymphoma. Positron emission tomography/computed tomography performed after chemotherapy showed a high 18F-fluoro-2deoxy-D-glucose uptake in both ovaries, which required distinguishing relapse. CMV oophoritis was diagnosed on histology following bilateral salpingo-oophorectomy. Although the patient later developed recurrent episodes of CMV antigenemia, after which complications of CMV retinitis appeared, and she ultimately died of CMV meningitis, surgical resection with antiviral medication resolved her abdominal symptoms and cleared CMV antigenemia for several weeks. It is therefore worth considering surgical resection in combination with antiviral drugs as a treatment option.

Keywords: Burkitt's lymphoma; cytomegalovirus oophoritis; foscarnet; positron emission tomography; pseudotumor.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Burkitt Lymphoma* / diagnosis
  • Burkitt Lymphoma* / drug therapy
  • Cytomegalovirus
  • Cytomegalovirus Infections* / diagnosis
  • Cytomegalovirus Infections* / drug therapy
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Oophoritis* / drug therapy

Substances

  • Antiviral Agents