A nickel-catalyzed site-selective intermolecular amidation of saturated C(sp3 )-H bonds is reported. This mild protocol exhibits a predictable reactivity pattern to incorporate amide functions at C(sp3 )-H sites adjacent to nitrogen and oxygen atoms in either cyclic or acyclic frameworks, thus offering a complementary reactivity profile to existing oxidative-type processes or metal-catalyzed C(sp3 )-N bond-forming reactions operating via two-electron manifolds.
Keywords: Amidation; C−H Functionalization; Hydrogen Atom Transfer; Nickel Catalysis; Nitrene Insertion.
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