Occurrence and ecological risk assessment of antibiotic residues in urban wastewater discharged into the coastal environment of the Persian Gulf (the case of Bandar Abbas)

Abstract

This is the first attempt to detect antibiotic residues released into the Persian Gulf marine environment. In particular, this study quantifies and assesses the ecological risks of amoxicillin (AMX) and azithromycin (AZM) residues in wastewater outfalls from Bandar Abbas, one of the major coastal cities in southern Iran. The wastewater effluent samples were collected from two main wastewater discharging stations, Gursuzan and Suru, between December 2020 and February 2021. High-performance liquid chromatography (HPLC) analysis revealed the average concentration (± 95% CL) of AMX were 460 ± 230.0 μg L^-1 and 280 ± 100.6 μg L^-1 in Gursuzan and Suru stations. Mean AZM concentrations were also 264 ± 10.59 μg L^-1 and 295 ± 89.75 μg L^-1 in these stations, respectively. Pooled data indicated that there are 335.17 ± 105.11 and 288.17 ± 37.94 μg of AMX and AZM residues in the wastewater per liter. The values of potential ecological risk, hazard quotient (HQ), were extensively above 10 (AMX: 90,586.5 and AZM: 5541.7) which suggest that these substances have a high health risk for the ecosystem and public. Given that Bandar Abbas wastewater treatment plant (WWTP) outlets are discharged at about 500 to 700 L s^-1, the daily maximum potential AMX and AZM released were estimated to be 19.05 (± 0.283) × 10³ and 14.74 (± 0.113) × 10³ g day^-1, respectively (α = 0.05). Our findings show that there is a concerning volume of antibiotic residues released into the northern Persian Gulf, and hence urgent policies and actions are necessary to reduce this pollution.

Keywords: Antibiotic residues; Emerging contaminants; Persian Gulf; Risk assessment; Wastewater.