Exosomes as Potential Functional Nanomaterials for Tissue Engineering

Yang Yao; Yuhuan Jiang; Jialu Song; Ruojing Wang; Zhaoping Li; Lei Yang; Weimin Wu; Luyue Zhang; Qiang Peng

doi:10.1002/adhm.202201989

Exosomes as Potential Functional Nanomaterials for Tissue Engineering

Adv Healthc Mater. 2023 Jun;12(16):e2201989. doi: 10.1002/adhm.202201989. Epub 2022 Oct 17.

Authors

Yang Yao¹, Yuhuan Jiang¹, Jialu Song¹, Ruojing Wang¹, Zhaoping Li¹, Lei Yang¹, Weimin Wu¹, Luyue Zhang¹, Qiang Peng¹

Affiliation

¹ State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, Block 3, Renmin Road South, Chengdu, 610041, P. R. China.

PMID: 36253093
DOI: 10.1002/adhm.202201989

Abstract

Exosomes are cell-derived extracellular vesicles of 40-160 nm diameter, which carry numerous biomolecules and transmit information between cells. They are used as functional nanomaterials with great potential in biomedical areas, such as active agents and delivery systems for advanced drug delivery and disease therapy. In recent years, potential applications of exosomes in tissue engineering have attracted significant attention, and some critical progress has been made. This review gives a complete picture of exosomes and their applications in the regeneration of various tissues, such as the central nervous systems, kidney, bone, cartilage, heart, and endodontium. Approaches employed for modifying exosomes to equip them with excellent targeting capacity are summarized. Furthermore, current concerns and future outlook of exosomes in tissue engineering are discussed.

Keywords: exosomes; nanoparticles; regenerative medicine; targeted delivery; tissue engineering.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Exosomes*
Extracellular Vesicles*
Nanostructures*
Tissue Engineering