Higher maternal thyroid resistance indices were associated with increased neonatal thyroid-stimulating hormone- analyses based on the Huizhou mother-infant cohort

Shuyi Li; Yi Wu; Su-Juan Zhang; Guoyi Li; Yu Tao Xiang; Wei-Zhong Zhang; Wen-Jing Pan; Wei-Qing Chen; Yuan-Tao Hao; Wen-Hua Ling; Zhao-Min Liu

doi:10.3389/fendo.2022.937430

Higher maternal thyroid resistance indices were associated with increased neonatal thyroid-stimulating hormone- analyses based on the Huizhou mother-infant cohort

Front Endocrinol (Lausanne). 2022 Sep 30:13:937430. doi: 10.3389/fendo.2022.937430. eCollection 2022.

Authors

Shuyi Li^{1

2}, Yi Wu^{1

2}, Su-Juan Zhang^{1

2}, Guoyi Li^{2

3}, Yu Tao Xiang⁴, Wei-Zhong Zhang⁵, Wen-Jing Pan⁵, Wei-Qing Chen², Yuan-Tao Hao², Wen-Hua Ling^{1

2}, Zhao-Min Liu^{1

2}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
² School of Public Health, Sun Yat-sen University, Guangzhou, China.
³ Department of Clinical Nutrition, The First Huizhou Central Hospital, Huizhou, China.
⁴ Unit of Psychiatry, Department of Public Health and Medicinal Administration, University of Macao, Macao, Macau SAR, China.
⁵ Department of Pediatrics and Department of Health-care for Children Huizhou First Mother and Child Health-Care Hospital, Huizhou, China.

Abstract

Objectives: This study aimed to explore the relationship of maternal thyroid function and thyroid resistance parameters with neonatal thyroid-stimulating hormone (TSH).

Methods: This work was a longitudinal study. Singleton pregnant women without a history of thyroid disorders were recruited in their first prenatal visit from October 2018 to June 2020. Maternal thyroid markers including TSH, free triiodothyronine (FT3), free thyroxine (FT4), and neonatal TSH were tested in the clinical laboratory of the hospital by electrochemiluminescence immunoassay. Thyroid resistance indices including Thyroid Feedback Quantile-based Index (TFQI), TSH index (TSHI), and thyrotroph T4 resistance index (TT4RI) were estimated in accordance with maternal FT4 and TSH levels. Multivariable linear and logistic regression was applied to explore the associations of maternal thyroid indices with infantile TSH level.

Results: A total of 3,210 mothers and 2,991 newborns with valid TSH data were included for analysis. Multivariable linear regression indicated that maternal thyroid variables were significantly and positively associated with neonatal TSH levels with standardized coefficients of 0.085 for TSH, 0.102 for FT3, 0.100 for FT4, 0.076 for TSHI, 0.087 for TFQI, and 0.089 for TT4RI (all P < 0.001). Compared with the lowest quartile, the highest quartile of TSHI [odds ratio (OR) = 1.590, 95% CI: 0.928-2.724; P_trend = 0.025], TFQI (OR = 1.746, 95% CI: 1.005-3.034; P_trend = 0.016), and TT4RI (OR = 1.730, 95% CI: 1.021-2.934; P_trend = 0.030) were significantly associated with an increased risk of elevated neonatal TSH (>5 mIU/L) in a dose-response manner.

Conclusion: The longitudinal data demonstrated that maternal thyroid resistance indices and thyroid hormones in the first half of gestation were positively associated with neonatal TSH levels. The findings offered an additionally practical recommendation to improve the current screening algorithms for congenital hypothyroidism.

Keywords: Maternal thyroid function; birth cohort; neonatal TSH; thyroid resistance indices; thyroid sensitivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Hyperthyroidism*
Infant, Newborn
Longitudinal Studies
Mothers
Pituitary Diseases*
Pregnancy
Thyroid Hormones
Thyrotropin
Thyroxine
Triiodothyronine

Substances

Thyroid Hormones
Triiodothyronine
Thyrotropin
Thyroxine