The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism

Fan Yang; Yanli Song; Haoming Song; Weiping Zheng; Lemin Wang

doi:10.1155/2022/9610071

The High Expression of Adhering and Circulating Integrin Serves as a Diagnostic Marker in Venous Thromboembolism

Comput Math Methods Med. 2022 Oct 7:2022:9610071. doi: 10.1155/2022/9610071. eCollection 2022.

Authors

Fan Yang¹, Yanli Song², Haoming Song³, Weiping Zheng¹, Lemin Wang³

Affiliations

¹ Department of Clinical Laboratory, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
² Department of Internal Emergency, Tongji Hospital, Tongji University School of Medicine, Shanghai, 20006, China.
³ Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.

Abstract

Objective: To investigate the diagnostic value of circulating integrins β1, 2, and 3 in venous thrombosis (VTE).

Materials and methods: A total of 474 VTE patients and 306 patients with nonhigh risk for VTE as the control group were studied. Levels of adhering integrins β1, 2, and 3 were detected by flow cytometry. Levels of circulating integrins β1, 2, and 3 in serum were measured by enzyme-linked immunosorbent assay.

Results: We found that integrins β1, 2, and 3 were expressed highly both in serum and on the surface of leukocytes and platelets in venous thromboembolism. The levels of circulating integrins β1, 2, and 3 are positively correlated with adhering integrins. It showed excellent clinical diagnostic performance of circulating integrins β1, 2, and 3 in venous thromboembolism.

Conclusions: Integrin subunit β can be used as a diagnostic marker with high sensitivity and specificity for venous thromboembolism.

Publication types

Retracted Publication

MeSH terms

Flow Cytometry
Humans
Integrin beta1 / metabolism
Integrins* / metabolism
Leukocytes
Venous Thromboembolism* / diagnosis
Venous Thromboembolism* / metabolism

Substances

Integrin beta1
Integrins