Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle

Manimegalai Sengani; Shreya Chakraborty; Menaka Priya Balaji; Rajakumar Govindasamy; Tahani Awad Alahmadi; Sami Al Obaid; Indira Karuppusamy; Nguyen Thuy Lan Chi; Kathirvel Brindhadevi; Devi Rajeswari V

doi:10.1016/j.envres.2022.114475

Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle

Environ Res. 2023 Jan 1;216(Pt 2):114475. doi: 10.1016/j.envres.2022.114475. Epub 2022 Oct 14.

Affiliations

¹ Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Rampuram, Chennai, 87, India.
² Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 14, Tamil Nadu, India.
³ Department of Orthodontics Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
⁴ Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, PO Box-2925, Riyadh, 11461, Saudi Arabia.
⁵ Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia.
⁶ Research Center for Strategic Materials, Corrosion Resistant Steel Group, National Institute for Materials Science (NIMS), Tsukuba, Japan.
⁷ School of Engineering and Technology, Van Lang University, Ho Chi Minh City, Viet Nam.
⁸ Computational Engineering and Design Research Group, School of Engineering and Technology, Van Lang University, Ho Chi Minh City, Viet Nam. Electronic address: brindhadevi.k@vlu.edu.vn.
⁹ Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 14, Tamil Nadu, India. Electronic address: sdevirajeswari@gmail.com.

PMID: 36244440
DOI: 10.1016/j.envres.2022.114475

Abstract

Non-enzymatic glycation of biomolecules results in advanced glycation end products (AGEs), which are responsible for secondary complications in diabetes. Inhibiting methyl glyoxal (MGO) induced advanced glycation end product (AGE) formation is the only way to alleviate diabetic complications. This study aimed to look into the abilities of herbal extract Kigelia africana and K. africana synthesized zinc oxide nanoparticles (ZnONPs) to inhibit the emergence of MG-derived AGEs. The study intended to determine antioxidant and AGE inhibition of the plant extract and ZnONPs. ZnONPs were tested for the efficiency of anti-diabetic activity in streptozotocin-induced diabetic Wister rats. We discovered that the MGO-trapping effects on the prevention of AGE production were mediated by the downregulation of the amplification of MGO-trapping impacts on the hypoglycemic and antihyperlipidemic mechanisms of ZnONPs. According to histological findings, the treatment with ZnONPs also successfully lowers inflammation in the hepatic and renal tissues. Overall, future mechanistic research could establish ZnONPs potential anti-diabetic properties.

Keywords: Advanced glycation end products; Anti-diabetic; Antioxidant; Diabetes; Polyphenols; Zinc oxide nanoparticles (ZnONPs).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diabetes Mellitus*
Glycation End Products, Advanced
Magnesium Oxide
Nanoparticles*
Pyruvaldehyde / pharmacology
Rats
Rats, Wistar
Zinc Oxide* / pharmacology

Substances

Zinc Oxide
Glycation End Products, Advanced
Magnesium Oxide
Pyruvaldehyde