Estimate of activity discharged into the sewer network in neuroendocrine treatments with 177Lu-DOTA-TATE

Raquel Barquero; Javier Velasco; Carlos Andres; Ricardo Torres; Ricardo Ruano

doi:10.1016/j.apradiso.2022.110459

Estimate of activity discharged into the sewer network in neuroendocrine treatments with ¹⁷⁷Lu-DOTA-TATE

Appl Radiat Isot. 2022 Dec:190:110459. doi: 10.1016/j.apradiso.2022.110459. Epub 2022 Sep 24.

Authors

Raquel Barquero¹, Javier Velasco², Carlos Andres², Ricardo Torres², Ricardo Ruano²

Affiliations

¹ Hospital Clinico Universitario de Valladolid Valladolid, Valladolid, Spain. Electronic address: rbarquerosa@saludcastillayleon.es.
² Hospital Clinico Universitario de Valladolid Valladolid, Valladolid, Spain.

PMID: 36242930
DOI: 10.1016/j.apradiso.2022.110459

Abstract

The urine of patients treated for neuroendocrine tumors with ¹⁷⁷Lu is a liquid radioactive waste. The total body activity retained by the patient is quantified with SPECT-CT image 1 day after administration. From the activity of ¹⁷⁷Lu in patient after 1 day Apat_Lu177_1d, the activity in urine after 1 day Aurine_Lu177_1d is determined, as well as the activity of ^177mLu Aurine_Lu177m_1d that accompanies ¹⁷⁷Lu as an impurity. Admitting the patient 24 hours in a dedicated room with storage tanks reduces the discharged activity below the permitted limits.

MeSH terms

Humans
Neuroendocrine Tumors* / diagnostic imaging
Neuroendocrine Tumors* / radiotherapy
Octreotide / therapeutic use
Organometallic Compounds* / therapeutic use
Radiopharmaceuticals / therapeutic use
Tomography, Emission-Computed, Single-Photon

Substances

1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
Radiopharmaceuticals
Octreotide
Organometallic Compounds