DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease

Bindu D Paul

doi:10.1016/j.cell.2022.09.029

DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease

Cell. 2022 Oct 13;185(21):3854-3856. doi: 10.1016/j.cell.2022.09.029.

Author

Bindu D Paul¹

Affiliation

¹ Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Lieber Institute for Brain Development, Baltimore, MD 21205, USA. Electronic address: bpaul8@jhmi.edu.

Abstract

Although women are at higher risk for Alzheimer's disease and other tauopathies, the underlying mechanisms are unclear. In this issue of Cell, Yan et al. show that aberrantly high activity of X-linked USP11 deubiquitinase in women impairs clearance of tau, the principal component of neurofibrillary tangles in Alzheimer's disease.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Alzheimer Disease* / genetics
Deubiquitinating Enzymes
Female
Humans
Neurofibrillary Tangles
Tauopathies*
Thiolester Hydrolases
tau Proteins / genetics

Substances

USP11 protein, human
tau Proteins
Thiolester Hydrolases
Deubiquitinating Enzymes

Abstract

Publication types

MeSH terms

Substances

Grants and funding