Postprandial Glycemic and Insulinemic Response by a Brewer's Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients. 2022 Sep 21;14(19):3916. doi: 10.3390/nu14193916.

Abstract

Dietary fiber exerts beneficial effects on human health reducing the risk factors of metabolic related diseases such as hyperglycemia, insulin resistance, and hypercholesterolemia. The aim of this study is to demonstrate the efficacy of a food supplement based on brewer's spent grain (BSG) extract in the reduction of postprandial glycemia and insulinemia in normoglycemic subjects. BSG was chemically characterized, revealing the presence of resistant starch (14.64 g/100 g), arabinoxylans (7.50 g/100 g), β-glucans (1.92 g/100 g) and other soluble fibers (6.43 g/100 g), and bioaccessible ferulic acid (91.3 mg/100 g). For the clinical study, 40 normoglycemic subjects were randomized into two groups, 1 and 2 (n = 20), for a cross-over clinical design and received either BSG extract-based food supplement or placebo. Postprandial blood glucose values were significantly lower than corresponding values in the placebo group after 90 and 120 min, while at the baseline and in the first 60 min, the two glycemic curves overlapped substantially. This improved clinical outcome was corroborated by significant reductions in postprandial insulinemia. None of the subjects reported adverse effects. This study showed that the tested BSG extract-based food supplement improves glucose metabolism and insulinemic response in normoglycemic subjects with at most a mild insulin resistance.

Keywords: brewer’s spent grains; clinical trial; dietary fiber; food supplement; insulinemia; postprandial glycemia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Blood Glucose / metabolism
  • Cross-Over Studies
  • Dietary Fiber
  • Dietary Supplements
  • Edible Grain / chemistry
  • Glucose Intolerance*
  • Humans
  • Insulin
  • Insulin Resistance*
  • Postprandial Period
  • Resistant Starch
  • beta-Glucans* / analysis

Substances

  • Blood Glucose
  • Dietary Fiber
  • Insulin
  • Resistant Starch
  • beta-Glucans

Grants and funding

This research received no external funding.