Carbazole Derivatives as Potential Antimicrobial Agents

Molecules. 2022 Oct 4;27(19):6575. doi: 10.3390/molecules27196575.

Abstract

Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections. Among many nitrogen-containing heterocycles, carbazole derivatives have shown significant biological activities, of which its antimicrobial and antifungal activities are the most studied. In this review, miscellaneous carbazole derivatives and their antimicrobial activity are discussed (articles published from 1999 to 2022).

Keywords: antibacterial; antifungal; antimicrobial; carbazole derivatives; drug resistance.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / pharmacology
  • Antifungal Agents* / pharmacology
  • Carbazoles / pharmacology
  • Microbial Sensitivity Tests
  • Nitrogen
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Carbazoles
  • Nitrogen