Bio-Nanohybrid Gelatin/Quantum Dots for Cellular Imaging and Biosensing Applications

Int J Mol Sci. 2022 Oct 6;23(19):11867. doi: 10.3390/ijms231911867.

Abstract

The bio-nanohybrid gelatin protein/cadmium sulfide (Gel/CdS) quantum dots (QDs) have been designed via a facile one-pot strategy. The amino acids group of gelatin chelate Cd2+ and grow CdS QDs without any agglomeration. The 1H NMR spectra indicate that during the above process there are no alterations of the gelatin protein structure conformation and chemical functionalities. The prepared Gel/CdS QDs were characterized and their potential as a system for cellular imaging and the electrochemical sensor for hydrogen peroxide (H2O2) detection applications were investigated. The obtained results demonstrate that the developed Gel/CdS QDs system could offer a simple and convenient operating strategy both for the class of contrast agents for cell labeling and electrochemical sensors purposes.

Keywords: biocompatible; biosensor; cellular imaging; gelatin; quantum dots.

MeSH terms

  • Amino Acids
  • Biosensing Techniques* / methods
  • Cadmium
  • Cadmium Compounds
  • Contrast Media
  • Gelatin
  • Hydrogen Peroxide
  • Quantum Dots* / chemistry
  • Sulfides / chemistry

Substances

  • Amino Acids
  • Cadmium Compounds
  • Contrast Media
  • Sulfides
  • Cadmium
  • cadmium sulfide
  • Gelatin
  • Hydrogen Peroxide

Grants and funding

The authors thank Ghent University for providing financial support while pursuing this research. Sangram Keshari Samal highly acknowledges the Ramanujan fellowship (SB/S2/RJN-038/2016) of the Department of Science and Technology and Ramalingaswami Re-entry fellowship (Ref: D.O. No. BT/HRD/35/02/2006) of Department of Biotechnology, Government of India.