Asymptomatic pleural thickening with effusion as the only manifestation of IgG4-related disease

Shailesh Kolekar; Katrine Fjaellegaard; Jesper Koefod Petersen; Karen Ege Olsen; Paul Frost Clementsen; Uffe Bodtger

doi:10.1002/rcr2.663

Asymptomatic pleural thickening with effusion as the only manifestation of IgG4-related disease

Respirol Case Rep. 2020 Dec 8;9(1):e00663. doi: 10.1002/rcr2.663. eCollection 2021 Jan.

Authors

Shailesh Kolekar¹, Katrine Fjaellegaard^{1

2

3}, Jesper Koefod Petersen^{1

2

3}, Karen Ege Olsen⁴, Paul Frost Clementsen^{1

5

6}, Uffe Bodtger^{1

2

3}

Affiliations

¹ Department of Internal Medicine Zealand University Hospital Roskilde Denmark.
² Department of Respiratory Medicine Naestved Hospital Naestved Denmark.
³ Institute of Regional Health Research University of Southern Denmark Odense Denmark.
⁴ Department of Pathology Odense University Hospital Odense Denmark.
⁵ Copenhagen Academy for Medical Education and Simulation (CAMES), Rigshospitalet University of Copenhagen and the Capital Region of Denmark Copenhagen Denmark.
⁶ Department of Clinical Medicine University of Copenhagen Copenhagen Denmark.

Abstract

Immunoglobulin G4 (IgG4)-related disease is a systemic fibroinflammatory disorder that can affect almost any tissue. Isolated IgG4 pleural disease is a rare manifestation and, when present, is usually described in patients presenting with dyspnoea. We present a case of asymptomatic isolated IgG4 pleural effusion and highlight that IgG4-related disease should be remembered as a differential diagnosis in patients with pleural effusion and pleural thickening, even if asymptomatic and without any other organ involvement.

Keywords: Fibroinflammatory disorder; IgG4‐related disease; pleural fluid.

Publication types

Case Reports